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Identification of nsSNPs of transcription factor E2F1 predisposing individuals to lung cancer and head and neck cancer.

Mutation research - 1 Jan 2000

Singh Sanjay, Yennamalli Ragothaman M, Gupta Manish, Changotra Harish

Abstract excerpt

E2Fs transcription factors family is involved in the G1/S transition and DNA replication and their deregulated expression have been reported in various human cancers. Studies have shown that the genetic variants of E2F1 family members play an important role in head and neck carcinogenesis. In this study, we predicted six highly deleterious nsSNPs (C227F, R252H, V295D, C298Y, R56W, and Y59C) of E2F1 gene through...

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PMID: 32407972
DOI: 10.1016/j.mrfmmm.2020.111704

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