Article

High-Risk Human Papillomavirus E7 Alters Host DNA Methylome and Represses <i>HLA-E</i> Expression in Human Keratinocytes

2017-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Human papillomavirus (HPV) infection distinctly alters methylation patterns in HPV-associated cancer. We have recently reported that HPV E7-dependent promoter hypermethylation leads to downregulation of the chemokine CXCL14 and suppression of antitumor immune responses. To investigate the extent of gene expression dysregulated by HPV E7-induced DNA methylation, we analyzed parallel global gene...

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Literature Corpus work: 602bcaf7-ab1b-50d9-839d-f8c0890e8e02
DOI: 10.1101/132902

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