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Article

Epigenetic Silencing of Interferon-κ in Human Papillomavirus Type 16–Positive Cells

4 Nov 2009

Abstract excerpt

We have investigated interferon-kappa (IFN-kappa) regulation in the context of human papillomavirus (HPV)-induced carcinogenesis using primary human foreskin keratinocytes (HFK), immortalized HFKs encoding individual oncoproteins of HPV16 (E6, E7, and E6/E7), and cervical carcinoma cells. Here, IFN-kappa was suppressed in the presence of E6, whereas its expression was not affected in HFKs or E7-immortalized HFKs....

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PMID: 19887612
DOI: 10.1158/0008-5472.can-09-0550

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