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Article

Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma

5 Feb 2013

Abstract excerpt

BACKGROUND: Human papillomavirus-positive (HPV+) head and neck squamous cell carcinoma (HNSCC) represents a distinct clinical and epidemiological condition compared with HPV-negative (HPV-) HNSCC. To test the possible involvement of epigenetic modulation by HPV in HNSCC, we conducted a genome-wide DNA-methylation analysis. METHODS: Using laser-capture microdissection of 42 formalin-fixed paraffin wax-embedded...

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PMID: 23419152
DOI: 10.1186/gm419

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