Article

Cholesterol binding to the transmembrane region of a group 2 HA of Influenza virus is essential for virus replication affecting both virus assembly and HA’s fusion activity

2019-04-08

Abstract excerpt

<h4>ABSTRACT</h4> Hemagglutinin (HA) of Influenza virus is incorporated into cholesterol enriched, nanodomains of the plasma membrane. Phylogenetic group 2 HAs contain the conserved cholesterol consensus motif (CCM) YKLW in the transmembrane region. We previously reported that mutations in the CCM retarded intracellular transport of HA and decreased its nanodomain association. Here we analyzed whether cholesterol...

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Literature Corpus work: 5ffa94af-3063-54d9-971d-74382becf57e
DOI: 10.1101/598953

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