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Article

Palmitoylation of the hemagglutinin of influenza B virus by ER-localized DHHC enzymes 1, 2, 4, and 6 is required for efficient virus replication.

Journal of virology - 31 Oct 2023

Meng Xiaorong, Veit Michael

Abstract excerpt

IMPORTANCE: Influenza viruses are a public health concern since they cause seasonal outbreaks and occasionally pandemics. Our study investigates the importance of a protein modification called "palmitoylation" in the replication of influenza B virus. Palmitoylation involves attaching fatty acids to the viral protein hemagglutinin and has previously been studied for influenza A virus. We found that this...

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Identifiers

PMID: 37792001
DOI: 10.1128/jvi.01245-23
PMCID: PMC10617437

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