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Article

Aminoterminal amphipathic α-helix AH1 of hepatitis C virus nonstructural protein 4B possesses a dual role in RNA replication and virus production.

PLoS pathogens - 1 Oct 2014

Gouttenoire Jérôme, Montserret Roland, Paul David, Castillo Rosa, Meister Simon, Bartenschlager Ralf, Penin François, Moradpour Darius

Abstract excerpt

Nonstructural protein 4B (NS4B) is a key organizer of hepatitis C virus (HCV) replication complex formation. In concert with other nonstructural proteins, it induces a specific membrane rearrangement, designated as membranous web, which serves as a scaffold for the HCV replicase. The N-terminal part of NS4B comprises a predicted and a structurally resolved amphipathic α-helix, designated as AH1 and AH2,...

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Source

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Identifiers

PMID: 25392992
DOI: 10.1371/journal.ppat.1004501
PMCID: PMC4231108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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