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Article

Differential cholesterol binding by class II fusion proteins determines membrane fusion properties.

Journal of virology - 1 Sept 2008

Umashankar M, Sánchez-San Martín Claudia, Liao Maofu, Reilly Brigid, Guo Alice, Taylor Gwen, Kielian Margaret

Abstract excerpt

The class II fusion proteins of the alphaviruses and flaviviruses mediate virus infection by driving the fusion of the virus membrane with that of the cell. These fusion proteins are triggered by low pH, and their structures are strikingly similar in both the prefusion dimer and the postfusion homotrimer conformations. Here we have compared cholesterol interactions during membrane fusion by these two groups of...

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Identifiers

PMID: 18632857
DOI: 10.1128/JVI.00975-08
PMCID: PMC2546879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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