Article
TRIM29 promotes DNA virus infections by inhibiting innate immune response
10 Oct 2017
Abstract excerpt
Abstract Many double-stranded DNA viruses, such as Epstein-Barr virus, can establish persistent infection, but the underlying virus–host interactions remain poorly understood. Here we report that in human airway epithelial cells Epstein-Barr virus induces TRIM29, a member of the TRIM family of proteins, to inhibit innate immune activation. Knockdown of TRIM29 in airway epithelial cells enhances type I interferon...