Article

Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytes

2020-09-03

Abstract excerpt

<h4>SUMMARY</h4> Pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLC) have shown great potential as an alternative to primary human hepatocytes (PHH) for in vitro modeling. Several differentiation protocols have been described to direct PSC towards the hepatic fate, although the resulting HLC have shown more a fetal than adult phenotype. Here, by leveraging recent knowledge of the signaling pathways i...

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Literature Corpus work: 73869c3e-1ea9-506e-aeae-974c5c011071
DOI: 10.1101/2020.09.02.280172

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