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Article

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

19 Aug 2011

Abstract excerpt

The availability of pluripotent stem cells offers the possibility of using such cells to model hepatic disease and development. With this in mind, we previously established a protocol that facilitates the differentiation of both human embryonic stem cells and induced pluripotent stem cells into cells that share many characteristics with hepatocytes. The use of highly defined culture conditions and the avoidance...

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PMID: 21852396
DOI: 10.1242/dev.062547

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