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Article

Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector.

Stem cell research & therapy - 4 Nov 2019

Ballester Maria, Bolonio Miguel, Santamaria Ramon, Castell José V, Ribes-Koninckx Carmen, Bort Roque

Abstract excerpt

BACKGROUND: Human fibroblasts can be reprogrammed into induced hepatocyte-like cells through the expression of a set of transcription factors. Although the generation of induced hepatocyte-like cells by HNF4A, HNF1A, and FOXA3 expression has proven to be a robust experimental strategy, using multiple lentivirus results in a highly variable heterogeneous population. METHODS: We designed and implemented a novel...

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Identifiers

PMID: 31685034
DOI: 10.1186/s13287-019-1416-5
PMCID: PMC6829923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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