Article

Hsa-miR-92a-3p regulates cell-cycle and signaling programs during human extra-embryonic lineage commitment

2026-05-04

Abstract excerpt

<h4>ABSTRACT</h4> MicroRNA (miRNA) levels increase during human embryonic genome activation (EGA) and have been implicated in the first lineage decisions. Re-analyzing single-cell and bulk small RNA-seq (sRNA-seq) from human and mouse embryos, together with new sRNA-seq of naïve human embryonic stem cells (hESCs) differentiated into hypoblast-like cells (HLCs) and extra-embryonic mesoderm (EXM)-like cells (EXMCs)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e417700-4a59-5a62-a908-b993e8987495
DOI: 10.64898/2026.04.29.721579

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hsa-miR-92a-3p regulates cell-cycle and signaling programs during human extra-embryonic lineage commitmentDOI 10.64898/2026.04.29.721579Read

SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and BlastoidsSemantic proximity Read

microRNA Expression during Trophectoderm SpecificationSemantic proximity Read

Dissecting Small Noncoding RNA Landscapes in Mouse Preimplantation Embryos and Human Blastoids for Modeling Early Human EmbryogenesisSemantic proximity Read

Rif1 and Hmgn3 regulate the conversion of murine trophoblast stem cellsSemantic proximity Read

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesisSemantic proximity Read

Spatio-temporal analysis of human preimplantation development reveals dynamics of epiblast and trophectodermSemantic proximity Read

A spatially resolved single cell atlas of human gastrulationSemantic proximity Read

Transcriptome Analysis during Human Trophectoderm Specification Suggests New Roles of Metabolic and Epigenetic GenesSemantic proximity Read

Combined mRNA and microRNA profiling reveals that miR-148a and miR-20b control human mesenchymal stem cell phenotype via EPAS1.Semantic proximity Read

A Single-Cell Transcriptomic Atlas of Symmetry Breaking Across Eutherian MammalsSemantic proximity Read

Research Resource: Small RNA-seq of Human Granulosa Cells Reveals miRNAs in FSHR and Aromatase GenesSemantic proximity Read

Epigenetic regulation of early human embryo developmentSemantic proximity Read