Article

The tumor suppressor protein PTEN undergoes amyloid-like aggregation in tumor cells

2020-11-30

Abstract excerpt

Protein aggregation is an underappreciated mechanism that may contribute to the loss- and oncogenic-gain-of-function of mutant tumor suppressors such as p53 and axin. In the present study, we describe amyloid-like aggregation behaviour of the second most frequently mutated tumor suppressor in human cancer, PTEN. In silico analysis revealed a particularly high aggregation vulnerability for this protein, which was...

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Literature Corpus work: 5fa79fd6-c067-56fc-b632-a7e8235bfa55
DOI: 10.1101/2020.11.30.402115

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