Article

Transcriptomic timeseries links hepatic gene expression to an early and self-limited systemic response to enteric infection

2026-04-10

Abstract excerpt

The liver receives microbe and host signals from the intestine via the portal vein, thereby connecting the gut to systemic physiology. Homeostatic control of the timing of systemic responses is critical to prevent the expansion and dissemination of gut microbes and to mitigate untoward effects from prolonged systemic inflammation, however these mechanisms remain enigmatic. Here, to determine the role of the liver...

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Literature Corpus work: 5fa15e7e-83e1-5eab-8074-a56ebbc1541e
DOI: 10.64898/2026.04.07.717127

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