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Article

Manipulation of focal Wnt activity via synthetic cells in a double-humanized zebrafish model of tumorigenesis.

International journal of cancer - 1 Jun 2021

Wang Lei, Long Jiang, Chen Huan, Sun Shaoyang, Lv Kunpeng, Li Qiang, Wang Xu

Abstract excerpt

The canonical Wnt signaling pathway is activated in numerous contexts, including normal and cancerous tissues. Here, we describe a synthetic cell-based therapeutic strategy that inhibits aberrant Wnt activity in specific focuses without interfering with the normal tissues in vivo. As a proof of principle, we generated a triple transgenic zebrafish liver cancer model that conditionally expressed human MET and...

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Identifiers

PMID: 33368276
DOI: 10.1002/ijc.33458

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