Article

Macrophages target PVR/CD155 on colorectal cancer cells via REVERBα

2026-01-29

Abstract excerpt

<h4>Background&Aims</h4> Patients with microsatellite-instable (MSI) colorectal cancer (CRC) benefit from immune checkpoint therapy. For patients with microsatellite-stable (MSS) non-MSI tumors targeting alternative immune checkpoints, such as the Poliovirus receptor (PVR/CD155), may extend response to checkpoint inhibitors and thereby improve outcomes. The drugable transcription factor REVERBα ( NR1D1 ) is a m...

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Literature Corpus work: 5f8757bf-6ed9-5318-a45d-b408c4de406c
DOI: 10.64898/2026.01.29.702476

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