Article

Immune Characterization of Metastatic Colorectal Cancer Patients Post Reovirus Administration

2020-06-09

Abstract excerpt

<title>Abstract</title> <p>Background: <italic>KRAS </italic>mutations are prevalent in 40-45% of patients with colorectal cancer (CRC) and targeting this gene has remained elusive. Viruses are well known immune sensitizing agents. The therapeutic efficacy of oncolytic reovirus in combination with chemotherapy is underway in a phase 1 study of metastatic CRC. This study evaluates the nature of immune response by...

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Literature Corpus work: 8ad4991a-87fe-5632-91de-514876c9c249
DOI: 10.21203/rs.3.rs-18123/v3

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