Evolutionary safety of death by mutagenesis

Abstract excerpt

Nucleoside analogs are a major class of antiviral drugs. Some act by increasing the viral mutation rate causing “death by mutagenesis” of the virus. Their mutagenic capacity, however, may lead to an evolutionary safety concern. We define evolutionary safety as a probabilistic assurance that the treatment will not generate an increased number of epidemiologically concerning mutated virus progeny. We develop a mathe...

Topics

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• Antiviral Agents
• Models, Genetic
• Mutagenesis
• Mutagens
• Mutation
• Ribavirin
• RNA Viruses
• Viruses

Identifiers and source

Literature Corpus work

5f774a4c-4e5f-5343-abcc-c6800ca481d2

DOI

10.1101/2022.03.10.483790