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Article

Lethal mutagenesis and evolutionary epidemiology.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Jun 2010

Martin Guillaume, Gandon Sylvain

Abstract excerpt

The lethal mutagenesis hypothesis states that within-host populations of pathogens can be driven to extinction when the load of deleterious mutations is artificially increased with a mutagen, and becomes too high for the population to be maintained. Although chemical mutagens have been shown to lead to important reductions in viral titres for a wide variety of RNA viruses, the theoretical underpinnings of this...

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Identifiers

PMID: 20478890
DOI: 10.1098/rstb.2010.0058
PMCID: PMC2880112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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