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Article

The evolutionary safety of mutagenic drugs should be assessed before drug approval.

PLoS biology - 1 Mar 2024

Lobinska Gabriela, Tretyachenko Vyacheslav, Dahan Orna, Nowak Martin A, Pilpel Yitzhak

Abstract excerpt

Some drugs increase the mutation rate of their target pathogen, a potentially concerning mechanism as the pathogen might evolve faster toward an undesired phenotype. We suggest a four-step assessment of evolutionary safety for the approval of such treatments.

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Identifiers

PMID: 38489394
DOI: 10.1371/journal.pbio.3002570
PMCID: PMC10971753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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