Article
Mutation rate and the efficacy of antimicrobial drug treatment.
The Lancet. Infectious diseases - 1 Jan 2003
Gerrish Philip J, García-Lerma J Gerardo
Abstract excerpt
Despite rapid progress in drug development, microbial infections in general are becoming increasingly difficult to treat as a result of the emergence of drug-resistant strains. In some cases, such as HIV-1, the early goal of eradicating infections with antimicrobial drugs is, for now, being replaced with the more pragmatic goal of controlling infections over long periods of time through a succession of...
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