Article

Primate-specific microRNA-1202 regulates dopaminergic neurogenesis by targeting APC2 and modulates WNT/β-catenin signaling pathway in midbrain organoid

2025-01-22

Abstract excerpt

<h4>ABSTRACT</h4> MicroRNAs (miRNAs) are generally evolutionarily conserved, but a small number of them are found exclusively in primates. MiR-1202 is a primate-specific miRNA that was previously revealed as being involved in major depression disorder (MDD). Moreover, the genomic locus where miR-1202 locates (6q25.3) is strongly associated with recurrent early-onset MDD and neurodevelopmental disorder. We hypothe...

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Literature Corpus work: 5f5b2f0b-530c-565b-b707-8f6446035bb3
DOI: 10.1101/2025.01.19.633822

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