Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia.

doi:10.1093/hmg/ddq316

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Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia.

Human molecular genetics - 15 Oct 2010

Saus Ester, Soria Virginia, Escaramís Geòrgia, Vivarelli Francesca, Crespo José M, Kagerbauer Birgit, Menchón José Manuel, Urretavizcaya Mikel, Gratacòs Mònica, Estivill Xavier

Abstract excerpt

Previous studies in mice have reported five different microRNAs (miRNAs; miR-219-1/132/183/96/182) to be modulators of the endogenous circadian clock and have presented experimental evidence for some of the genes involved in the molecular clock machinery as target sites. Moreover, disruption of circadian rhythms has long been implicated in the pathophysiology of major depression (MD). We investigated these miRNAs...

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Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia.

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