Article
MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.
Stem cells (Dayton, Ohio) - 1 Jun 2010
Smrt Richard D, Szulwach Keith E, Pfeiffer Rebecca L, Li Xuekun, Guo Weixiang, Pathania Manavendra, Teng Zhao-Qian, Luo Yuping, Peng Junmin, Bordey Angelique, Jin Peng, Zhao Xinyu
Abstract excerpt
The maturation of young neurons is regulated by complex mechanisms and dysregulation of this process is frequently found in neurodevepmental disorders. MicroRNAs have been implicated in several steps of neuronal maturation including dendritic and axonal growth, spine development, and synaptogenesis. We demonstrate that one brain-enriched microRNA, miR-137, has a significant role in regulating neuronal maturation....
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