Article

Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets

2019-05-09

Abstract excerpt

Development of drugs that allosterically regulate enzyme functions to treat disease is a costly venture. Screening mutations that mimic allosteric effectors in vitro will identify therapeutic regulatory targets enhancing the likelihood of developing a disease treatment at a reasonable cost. We demonstrate the potential of this approach utilizing human liver pyruvate kinase (hLPYK) as a model. Inhibition of hLPYK...

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Literature Corpus work: 5f472a1a-fd39-5fd5-a1e0-837306a966a3
DOI: 10.1101/632232

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