Article

Pitfalls and opportunities for applying PEER factors in single-cell eQTL analyses

2022-08-02

Abstract excerpt

Using latent variables in gene expression data can help correct spurious correlations due to unobserved confounders and increase statistical power for expression Quantitative Trait Loci (eQTL) detection. Probabilistic Estimation of Expression Residuals (PEER) is a widely used statistical method that has been developed to remove unwanted variation and improve eQTL discovery power in bulk RNA-seq analysis. However,...

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Literature Corpus work: 5f3e6d17-9cc6-59de-8399-7638260bbe47
DOI: 10.1101/2022.08.02.502566

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