Article
Correction for hidden confounders in the genetic analysis of gene expression.
Proceedings of the National Academy of Sciences of the United States of America - 21 Sept 2010
Listgarten Jennifer, Kadie Carl, Schadt Eric E, Heckerman David
Abstract excerpt
Understanding the genetic underpinnings of disease is important for screening, treatment, drug development, and basic biological insight. One way of getting at such an understanding is to find out which parts of our DNA, such as single-nucleotide polymorphisms, affect particular intermediary processes such as gene expression. Naively, such associations can be identified using a simple statistical test on all...
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