Article
CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer.
Genome research - 1 Sept 2013
Ling Hui, Spizzo Riccardo, Atlasi Yaser, Nicoloso Milena, Shimizu Masayoshi, Redis Roxana S, Nishida Naohiro, Gafà Roberta, Song Jian, Guo Zhiyi, Ivan Cristina, Barbarotto Elisa, De Vries Ingrid, Zhang Xinna, Ferracin Manuela, Churchman Mike, van Galen Janneke F, Beverloo Berna H, Shariati Maryam, Haderk Franziska, Estecio Marcos R, Garcia-Manero Guillermo, Patijn Gijs A, Gotley David C, Bhardwaj Vikas, Shureiqi Imad, Sen Subrata, Multani Asha S, Welsh James, Yamamoto Ken, Taniguchi Itsuki, Song Min-Ae, Gallinger Steven, Casey Graham, Thibodeau Stephen N, Le Marchand Loïc, Tiirikainen Maarit, Mani Sendurai A, Zhang Wei, Davuluri Ramana V, Mimori Koshi, Mori Masaki, Sieuwerts Anieta M, Martens John W M, Tomlinson Ian, Negrini Massimo, Berindan-Neagoe Ioana, Foekens John A, Hamilton Stanley R, Lanza Giovanni, Kopetz Scott, Fodde Riccardo, Calin George A
Abstract excerpt
The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability. We demonstrate that MYC, miR-17-5p, and miR-20a are up-regulated...
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