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Genetic disorders influencing lung formation and function at birth

9 Sept 2004

Abstract excerpt

Adaptation to air breathing at birth is dependent on formation and function of the lung. Lung morphogenesis is a complex process dependent on precise temporal-spatial control of cell proliferation, differentiation and behavior mediated by autocrine-paracrine signaling that instructs transcriptional processes during organogenesis. Mutations in genes causing severe, and often lethal, lung malformations include...

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PMID: 15358727
DOI: 10.1093/hmg/ddh252

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