Hypoxia-Induced Intrauterine Growth Retardation: Effects on Pulmonary Development and Surfactant Protein Transcription

Abstract excerpt

BACKGROUND AND OBJECTIVES: Preterm infants with intrauterine growth retardation (IUGR) reveal an increased risk for the development of acute and chronic pulmonary disorders, i.e. bronchopulmonary dysplasia (BPD). In order to investigate the effect of IUGR on pulmonary development, an easily reproducible animal model for fetal growth restriction has been established using hypoxia as a sole intervention in the last...

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