Article
A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours.
The Journal of pathology - 1 Sept 2017
Sackmann Sala Lucila, Boutillon Florence, Menara Giulia, De Goyon-Pélard Andréa, Leprévost Mylène, Codzamanian Julie, Lister Natalie, Pencik Jan, Clark Ashlee, Cagnard Nicolas, Bole-Feysot Christine, Moriggl Richard, Risbridger Gail P, Taylor Renea A, Kenner Lukas, Guidotti Jacques-Emmanuel, Goffin Vincent
Abstract excerpt
Castration-resistant prostate cancer is a lethal disease. The cell type(s) that survive androgen deprivation remain poorly described, despite global efforts to understand the various mechanisms of therapy resistance. We recently identified in wild-type (WT) mouse prostates a rare population of luminal progenitor cells that we called LSCmed according to their FACS profile (Lin- /Sca-1+ /CD49fmed ). Here, we...
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