Article

Taxane induces attenuation of the CXCR2/BCL-2 axis and sensitize prostate cancer to platinum-based treatments

2020-01-26

Abstract excerpt

<h4>Background</h4> Taxanes are the most active chemotherapy agents in metastatic castration resistant prostate cancer (mCRPC) patients, yet resistance almost invariably occurs representing an important clinical challenge. Taxane-platinum combinations have shown clinical benefit in a subset of patients but the mechanistic basis and biomarkers remain elusive. <h4>Objective</h4> To identify mechanisms and response...

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Literature Corpus work: 8ed05dd2-2922-5ec0-9dab-a8bc56f456ca
DOI: 10.1101/2020.01.20.912824

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