Article

Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling

1999-05-15

Abstract excerpt

Fibrillin is the principal structural component of the 10-12 nm diameter elastic microfibrils of the extracellular matrix. We have previously shown that both fibrillin molecules and assembled microfibrils are susceptible to degradation by serine proteases. In this study, we have investigated the potential catabolic effects of six matrix metalloproteinases (MMP-2, MMP-3, MMP-9, MMP-12, MMP-13 and MMP-14) on fibrill...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ef1b246-ea3c-5d00-9e08-e351c86f4f9e
DOI: 10.1042/0264-6021:3400171

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodellingDOI 10.1042/0264-6021:3400171Read

ADAMTS proteins as modulators of microfibril formation and functionSemantic proximity Read

Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function.Semantic proximity Read

Structure and function of the mammalian fibrillin gene family: implications for human connective tissue diseases.Semantic proximity Read

Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye diseaseSemantic proximity Read

New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies.Semantic proximity Read

Structural and functional failure of fibrillin‑1 in human diseases (Review)Semantic proximity Read

Targeted deletion of fibrillin-1 in the mouse eye results in ectopia lentis and other ocular phenotypes associated with Marfan syndromeSemantic proximity Read

Fibrillin‐rich microfibrils: Structural determinants of morphogenetic and homeostatic eventsSemantic proximity Read

The fibrillin-Marfan syndrome connection.Semantic proximity Read

Dissecting the fibrillin microfibril: structural insights into organization and function.Semantic proximity Read

Extracellular Microfibrils in Vertebrate Development and Disease ProcessesSemantic proximity Read

Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory TGFβ-binding siteSemantic proximity Read