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Article

ADAMTS proteins as modulators of microfibril formation and function

6 May 2015

Abstract excerpt

The ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs) protein superfamily includes 19 secreted metalloproteases and 7 secreted ADAMTS-like (ADAMTSL) glycoproteins. The possibility of functional linkage between ADAMTS proteins and fibrillin microfibrils was first revealed by a human genetic consilience, in which mutations in ADAMTS10, ADAMTS17, ADAMTSL2 and ADAMTSL4 were...

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PMID: 25957949
DOI: 10.1016/j.matbio.2015.05.004

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