Article
Structure and function of the mammalian fibrillin gene family: implications for human connective tissue diseases.
Molecular genetics and metabolism - 1 Dec 2012
Davis Margaret R, Summers Kim M
Abstract excerpt
Fibrillins and latent transforming growth factor β binding proteins (LTBPs) are components of the extracellular matrix of connective tissue. While fibrillins are integral to the 10nm microfibrils, and often associated with elastin, all family members are likely to have an additional role in regulating the bioavailability of transforming growth factor β (TGBβ). Both fibrillins and LTBPs are large glycoproteins,...
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