Article
Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration.
The Journal of cell biology - 7 Aug 2017
Belvindrah Richard, Natarajan Kathiresan, Shabajee Preety, Bruel-Jungerman Elodie, Bernard Jennifer, Goutierre Marie, Moutkine Imane, Jaglin Xavier H, Savariradjane Mythili, Irinopoulou Theano, Poncer Jean-Christophe, Janke Carsten, Francis Fiona
Abstract excerpt
Brain development involves extensive migration of neurons. Microtubules (MTs) are key cellular effectors of neuronal displacement that are assembled from α/β-tubulin heterodimers. Mutation of the α-tubulin isotype TUBA1A is associated with cortical malformations in humans. In this study, we provide detailed in vivo and in vitro analyses of Tuba1a mutants. In mice carrying a Tuba1a missense mutation (S140G),...
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