Article

<i>TUBA1A</i> mutations identified in lissencephaly patients dominantly disrupt neuronal migration and impair dynein activity

2018-07-25

Abstract excerpt

<h4>SUMMARY</h4> ‘Tubulinopathies’ are severe human brain malformations associated with mutations in tubulin genes. Despite the identification of many tubulin mutations in patients, we do not understand how these mutations impact the microtubule cytoskeleton, how the changes to microtubule function lead to brain malformations, or how different tubulin isotypes regulate microtubules to support normal neurodevelopm...

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Literature Corpus work: f30efc8d-7fee-5c1f-bccd-aaaa956cb72f
DOI: 10.1101/377440

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