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AMH protects the ovary from doxorubicin by regulating cell fate and the response to DNA damage

28 Jan 2025

Abstract excerpt

Anti-Müllerian hormone (AMH) protects the ovarian reserve from chemotherapy, and this effect is most pronounced with Doxorubicin (DOX). However, DOX toxicity and AMH rescue mechanisms in the ovary have remained unclear. Herein, we characterize the consequences of these treatments in ovarian cell types using scRNAseq. DOX-induced DNA damage activates Tp53 class mediators across ovarian cell types. In the...

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PMID: 39874288
DOI: 10.1073/pnas.2414734122

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