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Article

Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise

22 Aug 2011

Abstract excerpt

The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy-induced aging on the human ovary. Doxorubicin caused massive double-strand-DNA-breaks in primordial follicles, oocytes, and granulosa cells in a dose dependent...

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Share to Ovarian cancer diagnosis and treatment
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Share to Reproductive Biology and Fertility

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PMID: 21869459
DOI: 10.18632/aging.100363

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