Article

Investigating the Impacts of Sphingomyelinases on Extracellular Vesicle Cargo Sorting

2024-12-20

Abstract excerpt

<h4>SUMMARY</h4> Extracellular vesicles (EVs) form through regulated biogenesis processes involving sphingomyelinases (SMases), enzymes that metabolize sphingomyelin to produce ceramide—a lipid influencing membrane rigidity and essential for EV generation. This study explores the impact on EV protein and RNA cargoes resulting from inhibiting neutral SMase (NSM) and acid SMase (ASM) in human MCF7 cells. Our result...

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Literature Corpus work: 5ebadb12-e90d-5115-b427-b4261c55d530
DOI: 10.1101/2024.12.16.628770

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