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Article

The Acid Ceramidase Is a SARS-CoV-2 Host Factor

15 Aug 2022

Abstract excerpt

SARS-CoV-2 variants such as the delta or omicron variants, with higher transmission rates, accelerated the global COVID-19 pandemic. Thus, novel therapeutic strategies need to be deployed. The inhibition of acid sphingomyelinase (ASM), interfering with viral entry by fluoxetine was reported. Here, we described the acid ceramidase as an additional target of fluoxetine. To discover these effects, we synthesized an...

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PMID: 36010608
DOI: 10.3390/cells11162532

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