Article

Macrophage junctional adhesion molecule-like protein promotes NLRP3 inflammasome activation in the development of atherosclerosis

2024-07-19

Abstract excerpt

<title>Abstract</title> <p>Inflammation plays a crucial role in the progression of atherosclerosis. Junctional adhesion molecule-like protein (JAML), a type-I transmembrane glycoprotein, activates downstream signaling pathways. However, the precise role of macrophage-derived JAML in inflammation and atherosclerosis remains unclear. This study aimed to generate mice with macrophage-specific deletion or overexpress...

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Literature Corpus work: 5ea345a9-a85e-5789-9e72-51142d11e232
DOI: 10.21203/rs.3.rs-4560657/v1

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