The exploration to identify key molecules in the interaction between endothelial cells and mono-macrophages in atherosclerosis based on the single cell transcriptome.

Abstract excerpt

Coronary artery disease (CAD) is the leading cause of global cardiovascular deaths, and atherosclerosis (AS) is the characteristic pathological change in CAD. The interactions between monocytes/macrophages and endothelial cells play an essential role in the formation and progression of atherosclerotic plaques. In this study, we used published single-cell RNA sequencing datasets of calcified atherosclerotic core...

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