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Methylomic Analysis of Ovarian Cancers Identifies Tumor-Specific Alterations Readily Detectable in Early Precursor Lesions

14 Aug 2018

Abstract excerpt

Abstract Purpose: High-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess their potential to provide sensitive and specific detection of HGSOC at its earliest stages. Experimental Design: MethylationEPIC genome-wide methylation analysis...

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Share to Epigenetics and DNA Methylation
Share to Ovarian cancer diagnosis and treatment
Share to Reproductive Biology and Fertility

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PMID: 30108103
DOI: 10.1158/1078-0432.ccr-18-1199

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