Article

Multi-omics analysis in human retina uncovers ultraconserved <i>cis</i> -regulatory elements at rare eye disease loci

2023-06-12

Abstract excerpt

<h4>ABSTRACT</h4> Cross-species genome comparisons have revealed a substantial number of ultraconserved non-coding elements (UCNEs). Several of these elements have proved to be essential tissue- and cell type-specific cis -regulators of developmental gene expression. Here, we characterized a set of UCNEs as candidate CREs (cCREs) during retinal development and evaluated the contribution of their genomic variatio...

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Literature Corpus work: 49dc1b6b-5562-5132-96d3-3176976b86ef
DOI: 10.1101/2023.06.08.23291052

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