Article

Design of nanobody targeting SARS-CoV-2 spike glycoprotein using CDR-grafting assisted by molecular simulation and machine learning

2024-10-01

Abstract excerpt

The design of proteins capable to effectively bind to specific protein targets is crucial for developing therapies, diagnostics, and vaccine candidates for viral infections. Here, we introduce a complementarity-determining regions (CDRs)-grafting approach for designing nanobodies (Nbs) that target specific epitopes, with the aid of computer simulation and machine learning. As a proof-of-concept, we designed, evalu...

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Literature Corpus work: 5e763ccc-ecb9-5b90-be49-92025cb192e7
DOI: 10.1101/2024.09.30.615772

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