Computational and Experimental Antibody Affinity and Diagnostic Accuracy Quantification of SARS-CoV-2 SD2 Major Disulfide Loop Analog

Abstract excerpt

<h4>Introduction</h4> Synthetic oligopeptides provide a rapid and cost-efficient approach to developing antibodies and diagnostics for emerging viral variants. <h4>Methods</h4> This study computationally and experimentally characterized a synthetic peptide analog of the SARS-CoV-2 spike subdomain 2 major disulfide loop (SD2MDL), designated S621 (CPVAIHADQLTPTWRVYSTC). Binding affinity was computationally estimat...

Topics

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• Bacteriophages and microbial interactions
• Glycosylation and Glycoproteins Research
• Machine Learning in Bioinformatics
• Monoclonal and Polyclonal Antibodies Research
• SARS-CoV-2 and COVID-19 Research
• Transgenic Plants and Applications
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

b5f5ae79-444d-5cc2-ae01-a1aa9d151fd5

DOI

10.64898/2026.06.05.26353587