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Article

Systemic administration of Ivabradine, an HCN channel inhibitor, blocks spontaneous absence seizures

2021-02-17

Abstract excerpt

<h4>Summary</h4> <h4>Objective</h4> Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to be involved in the generation of absence seizures (ASs), and there is evidence that cortical and thalamic HCN channel dysfunctions may have a pro-absence role. Many HCN channel blockers are available, but their role in ASs has been investigated only by localized brain injection or in in vitro mode...

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Literature Corpus work
5e650fd3-b55c-561e-bb8c-bd0ecc1f875a
DOI
10.1101/2021.02.17.431588
Open publication

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Systemic administration of Ivabradine, an HCN channel inhibitor, blocks spontaneous absence seizuresDOI 10.1101/2021.02.17.431588
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