Article

A Multiscale Structural, Pharmacokinetic–Pharmacodynamic and Systems Pharmacology Framework Exploring a Plausible Interaction Between Cenobamate and Low-Dose Clobazam in Drug-Resistant Epilepsy

2026-08-12

Abstract excerpt

Drug-resistant epilepsy (DRE) remains a major therapeutic challenge despite the availability of numerous antiseizure medications (ASMs). Clinical observations suggest that, in some patients, the addition of low-dose clobazam to an established cenobamate regimen may be associated with improved seizure control. The biological basis of this observation, however, remains uncertain. This study aimed to develop a multis...

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Literature Corpus work: 359614f2-b72e-5c19-b85f-c3d1eb3be5d6
DOI: 10.20944/preprints202608.0825.v1

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A Multiscale Structural, Pharmacokinetic–Pharmacodynamic and Systems Pharmacology Framework Exploring a Plausible Interaction Between Cenobamate and Low-Dose Clobazam in Drug-Resistant EpilepsyDOI 10.20944/preprints202608.0825.v1Read

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